2024 Symposium on RNA Biology XV: RNA Tool and Target
November 14-15, 2024
Meeting Agenda
Thursday, November 14th
12:00 pm
Registration and arrival
12:25 pm
Welcome and opening remarks: Stacy Horner and Kate Meyer, Duke University
Session I: RNA Regulation and Structure
Session Chair: Qi Zhang, UNC-Chapel Hill
12:30 pm
Keynote Lecture: Mitch Guttman, Cal Tech
“RNA promotes the formation of spatial compartments throughout the nucleus”
1:10 pm
Joseph Yesselman, University of Nebraska
“High-throughput determination of RNA tertiary contact thermodynamics by quantitative DMS chemical mapping”
1:40 pm
Claire Fleurisson, UNC-Chapel Hill (15 minutes + 5 min Q&A)
“Contributions of RNA Structure Near Splice Sites to the Splicing Regulatory Code”
2:00 pm
Zoe Wright, NIEHS (15 minutes + 5 min Q&A)
“Structural and Biochemical Analyses Reveal that Spontaneous Base Flipping Helps Drive SARS-CoV-2 Protein Nsp15’s Preferences in dsRNA Substrates”
2:20 pm – 2:45 pm Break
Session II: RNA: Protein Interactions and RNA Modifications
Session Chair: Traci Hall, NIEHS
2:45 pm
Siggy Nachtergaele, Yale University
“Exploring the roles of RNA modifications in drug-resistant glioblastoma”
3:15 pm
Kotaro Nakanishi, The Ohio State University
“Gene silencing by cityRNAs”
3:45 pm
Kayla Mason, UNC-Chapel Hill (15 minutes + 5 min Q&A)
"The role of DDX3X in the initiation of cardiac sex-differential protein expression"
4:05 pm
Matt Tegowski, Duke University (15 minutes + 5 min Q&A)
"Single-cell m6A profiling in the mouse cortex reveals cell type-specific methylation profiles as well as changes during aging and stress"
The poster session and dinner will be on the 6th floor.
4:30 pm – 6:00 pm
Poster Session, Hors d’oeuvres and bar service.
6:00 pm Dinner
Friday, November 15th
10:00 am
Breakfast and networking
Session III: RNA Targeting and Therapeutics
Session Chair: Bruce Sullenger, Duke
10:30 am
Amanda Hargrove, University of Toronto
"Strategies to modulate the conformation and function of RNA with small molecules"
11:00 am
Wilton Snead, Duke University (15 minutes + 5 min Q&A)
"A multicomponent, out-of-equilibrium logic controls the assembly of nuclear paraspeckles"
11:20 am
Edgar Faison, UNC-Chapel Hill (15 minutes + 5 min Q&A)
"Chemical Visualization of Nascent RNA Folding with Co-Transcriptional TMO-MaP"
11:40 am
Diana Dou, Duke University (15 minutes + 5 min Q&A)
"A Complex issue: When 2 X’s need to Xist"
12:00 pm – 1:00 pm Lunch
Session IV: RNA Processing, Localization, and Translation
Session Chair: Mauro Calabrese, UNC-Chapel Hill
1:00 pm
Keynote Lecture: Geraldine Seydoux, Johns Hopkins University
"A structural role for mRNAs in germ granules?”
1:40 pm
Wayne Hemphill, University of Colorado Boulder (15 minutes + 5 min Q&A)
“A General Mechanism for Tunable RNA-Mediated Regulation of Chromatin-Binding Proteins”
2:00 pm
Alicia Darnell, Duke University (15 minutes + 5 min Q&A)
“Metabolic control of protein synthesis by ribosome fall-off”
2:20 pm – 2:40 pm Break
2:40 pm
Eric Wang, University of Florida
“RNA supply chain issues in repeat expansion diseases”
3:10 pm
Ru-pin Chi, NIEHS (15 minutes + 5 min Q&A)
“A death-promoting post-transcriptional mechanism in heat exposed cells”
3:30 pm
Taylor Niehoff, Duke University (15 minutes + 5 min Q&A)
“An unbiased screen identifies the PAXT connection as a modifier of rare codon-dependent expression”
3:50 pm
Lela Lackey, Clemson University (15 minutes + 5 min Q&A)
“Inflammation and alternative polyadenylation on alternative polyadenylation”
4:10 pm
Awards Presentation
4:30 pm – 6:00 pm
Reception, Hors d’oeuvres and bar service
Meeting Adjourns
Full Agenda
Thank You to our Sponsors
