Carissa Harvest working in the Miao lab described a new mouse model to study how granulomas, cellular fortresses built around foreign objects, kill pathogens. She showed that innate immune cells form a fully functional granuloma to wall off environmental bacteria like Chromobacterium violaceum and efficiently eliminate them. These immune cells must have intact inflammatory cellular death (pyroptotic) defenses and the ability to generate the toxic gas nitric oxide to kill the bacteria.
Congratulations to Jessica Portillo for her work on:
The Role of Host Genetics in Modulating the Beneficial Effects of the Gut Commensal Akkermansia muciniphila
Jessica Portillo of Raphael Valdivia's lab, is one of the 2023 Burroughs Wellcome Fund Graduate Diversity Enrichment Program (GDEP) awards recipient.