D. Bernard Amos Lecture: Arlene Sharpe, MD, PhD - "The Biology Behind PD-1 Checkpoint Blockade"

Arlene Sharpe, MD, PhD Harvard University "The Biology Behind PD-1 Checkpoint Blockade" Arlene Sharpe, MD, PhD is the Kolokotrones University Professor at Harvard University and Chair of the Department of Immunology at Harvard Medical School. She is a member of the Department of Pathology at Brigham and Women's Hospital, the Broad Institute of MIT and Harvard, Leader of the Cancer Immunology Program at Dana-Farber/Harvard Cancer Center, and Vice Director of the Gene Lay Institute of Immunology and Inflammation at Brigham and Women's Hospital, Massachusetts General Hospital, and Harvard Medical School. Dr. Sharpe earned her MD and PhD from Harvard Medical School and completed her residency in Pathology at Brigham and Women's Hospital. She is a leader in T cell costimulation. Her laboratory has discovered and elucidated functions of T cell costimulatory pathways, including immunoinhibitory functions of the CTLA-4 and PD-1 pathways, that has laid the foundation for immune checkpoint blockade therapy in cancer. Her laboratory investigates roles of T cell costimulatory pathways in regulating T cell tolerance, antimicrobial and antitumor immunity, and translating this understanding into therapies for autoimmune diseases and cancer. The D. Bernard Amos Research Lecture is supported by the D. Bernard Amos Fellowship Endowment. The lecture was established by the Department of Immunology to honor his memory and recognize his many contributions to medical research, education and service. A poster competition provides trainees with the opportunity to showcase their work and win awards. This event is facilitated by a student committee. Students and postdocs are invited to all speaker lunches as a networking opportunity after each seminar. Seminar refreshments are provided.