D. Bernard Amos Lecture: Pamela Schwartzberg, MD, PhD - "Integrating T cell signals: Lessons from PI3 Kinase"

Pamela Schwartzberg, MD, PhD Chief of the Cell Signaling and Immunity Section at NIAID NIH-UPenn Immunology Graduate Partnership Program Mentor "Integrating T cell signals: Lessons from PI3 Kinase" Pamela L. Schwartzberg received her B.A. from Princeton University and her M.D. and Ph.D. from the Columbia College of Physicians and Surgeons, Columbia University. During her Ph.D., she worked with Stephen Goff, Ph.D., on studies of retroviral replication and early work using homologous recombination to introduce mutations into the germline of mice - these studies helped open a new era in mouse genetics. After an internship at Boston Children's Hospital, Dr. Schwartzberg did a fellowship with Harold Varmus, M.D., at the National Cancer Institute, studying tyrosine-kinase signaling pathways as a special fellow of the Leukemia and Lymphoma Society (in collaboration with Michael Lenardo, M.D., National Institute of Allergy and Infectious Diseases). Dr. Schwartzberg started her own laboratory at the National Human Genome Research Institute at the end of 1997, was promoted to senior investigator with tenure in 2003 and recruited to the National Institute of Allergy and Infectious Diseases in 2018. Her laboratory's work has centered on the use of genetic, biochemical, cellular, and genomic studies to understand T-cell signaling, with a focus on pathways affected by primary immunodeficiencies. Dr. Schwartzberg is an adjunct faculty member at the University of Pennsylvania and has received several NIH awards for mentoring. She has served on numerous mentoring, reviewing, and editorial boards; is the recipient of a Searle Scholar's Award and the American Association of Immunologists BD-Pharmingen Biosciences Award for Early Career Scientists; and has been elected to the American Society for Clinical Investigation (ASCI), the Henry Kunkel Society, and the Association of American Physicians (AAP).